We are really happy to announce Prof. Daniel Gibbs from University of Birmingham as the next speaker of the HPSC. His research focuses on Plant Proteolysis and Signalling. He and his group want to investigate how plants use targeted protein degradation as a mechanism for sensing and transducing signals and regulating cellular processes, with a particular focus on the N-degron pathway of the ubiquitin proteasome system. We’re really looking forward to his presentation on 23th February titled “Build and destroy: roles for targeted protein degradation in plant development and stress response“.
Abstract: Proteins are essential functional components of cells, and as such their abundance and activity needs to be tightly controlled through their balanced production, modification and destruction. In eukaryotic organisms, a predominant mechanism for regulated protein degradation (proteolysis) is through the ubiquitin proteasome system (UPS). Here, proteins are marked for turnover by so called E3 ubiquitin ligases that catalyse the addition of ubiquitin molecules to the target protein. Compared to other kingdoms, the number of components linked to the UPS has significantly expanded in plant genomes, highlighting the enhanced importance of this cellular system in the plant lineage. Here I will present published and on-going collaborative work in this area, with a particular focus on how plants use protein degradation as a mechanism for coordinating cellular processes and sensing and responding to environmental signals and stresses. In particular I will highlight the importance of the ‘N-degron’ pathway of proteolysis for controlling flooding and low-oxygen-stress responses through functionally distinct transcriptional and epigenetic regulators.
Get more detailed information to the event here: https://rtg2498.uni-halle.de/hpsc_dgibbs/